PKR2 (pkr2_human)
FAMILY
Class A (Rhodopsin) Protein receptors Prokineticin receptors PKR2
GENE
PROKR2 (GPR73L1, PKR2)
ORGANISM
Human (Homo sapiens)
ALT. NAMES
Prokineticin receptor 2, PK-R2, G-protein coupled receptor 73-like 1, G-protein coupled receptor I5E, GPR73b, GPRg2
SOURCE
SWISSPROT
SEQUENCE
N-term | |||||||||
M
|
A
|
A
|
Q
|
N
|
G
|
N
|
T
|
S
|
F
|
10 |
T
|
P
|
N
|
F
|
N
|
P
|
P
|
Q
|
D
|
H
|
20 |
A
|
S
|
S
|
L
|
S
|
F
|
N
|
F
|
S
|
Y
|
30 |
G
|
D
|
Y
|
D
|
L
|
P
|
M
|
D
|
E
|
D
|
40 |
E
|
D
|
M
|
T
|
K
|
T
|
R
|
T
|
F
|
F
|
50 |
TM1 | |||||||||
A
|
A
|
K
|
I
|
V
|
I
|
G
|
I
|
A
|
L
|
60 |
A
|
G
|
I
|
M
|
L
|
V
|
C
|
G
|
I
|
G
|
70 |
N
|
F
|
V
|
F
|
I
|
A
|
A
|
L
|
T
|
R
|
80 |
ICL1 | TM2 | ||||||||
Y
|
K
|
K
|
L
|
R
|
N
|
L
|
T
|
N
|
L
|
90 |
L
|
I
|
A
|
N
|
L
|
A
|
I
|
S
|
D
|
F
|
100 |
L
|
V
|
A
|
I
|
I
|
C
|
C
|
P
|
F
|
E
|
110 |
M
|
D
|
Y
|
Y
|
V
|
V
|
R
|
Q
|
L
|
S
|
120 |
ECL1 | TM3 | ||||||||
W
|
E
|
H
|
G
|
H
|
V
|
L
|
C
|
A
|
S
|
130 |
V
|
N
|
Y
|
L
|
R
|
T
|
V
|
S
|
L
|
Y
|
140 |
V
|
S
|
T
|
N
|
A
|
L
|
L
|
A
|
I
|
A
|
150 |
I
|
D
|
R
|
Y
|
L
|
A
|
I
|
V
|
H
|
P
|
160 |
ICL2 | TM4 | ||||||||
L
|
K
|
P
|
R
|
M
|
N
|
Y
|
Q
|
T
|
A
|
170 |
S
|
F
|
L
|
I
|
A
|
L
|
V
|
W
|
M
|
V
|
180 |
S
|
I
|
L
|
I
|
A
|
I
|
P
|
S
|
A
|
Y
|
190 |
ECL2 | |||||||||
F
|
A
|
T
|
E
|
T
|
V
|
L
|
F
|
I
|
V
|
200 |
K
|
S
|
Q
|
E
|
K
|
I
|
F
|
C
|
G
|
Q
|
210 |
TM5 | |||||||||
I
|
W
|
P
|
V
|
D
|
Q
|
Q
|
L
|
Y
|
Y
|
220 |
K
|
S
|
Y
|
F
|
L
|
F
|
I
|
F
|
G
|
V
|
230 |
E
|
F
|
V
|
G
|
P
|
V
|
V
|
T
|
M
|
T
|
240 |
L
|
C
|
Y
|
A
|
R
|
I
|
S
|
R
|
E
|
L
|
250 |
W
|
F
|
K
|
A
|
V
|
P
|
G
|
F
|
Q
|
T
|
260 |
ICL3 | TM6 | ||||||||
E
|
Q
|
I
|
R
|
K
|
R
|
L
|
R
|
C
|
R
|
270 |
R
|
K
|
T
|
V
|
L
|
V
|
L
|
M
|
C
|
I
|
280 |
L
|
T
|
A
|
Y
|
V
|
L
|
C
|
W
|
A
|
P
|
290 |
F
|
Y
|
G
|
F
|
T
|
I
|
V
|
R
|
D
|
F
|
300 |
ECL3 | TM7 | ||||||||
F
|
P
|
T
|
V
|
F
|
V
|
K
|
E
|
K
|
H
|
310 |
Y
|
L
|
T
|
A
|
F
|
Y
|
V
|
V
|
E
|
C
|
320 |
I
|
A
|
M
|
S
|
N
|
S
|
M
|
I
|
N
|
T
|
330 |
ICL4 | H8 | ||||||||||
V
|
C
|
F
|
V
|
T
|
V
|
K
|
N
|
N
|
T
|
||
340 |
M
|
K
|
Y
|
F
|
K
|
K
|
M
|
M
|
L
|
L
|
350 |
C-term | |||||||||
H
|
W
|
R
|
P
|
S
|
Q
|
R
|
G
|
S
|
K
|
360 |
S
|
S
|
A
|
D
|
L
|
D
|
L
|
R
|
T
|
N
|
370 |
G
|
V
|
P
|
T
|
T
|
E
|
E
|
V
|
D
|
C
|
380 |
I
|
R
|
L
|
K
|
DIAGRAMS
Pick color:
Invitro Mutant Data: Increased binding/potency: >5-fold, >10-fold; Reduced binding/potency: >5-fold, >10-fold; No/low effect (<5-fold); and N/A
Pick color:
Invitro Mutant Data: Increased binding/potency: >5-fold, >10-fold; Reduced binding/potency: >5-fold, >10-fold; No/low effect (<5-fold); and N/A
MUTATIONS
PHYSIOLOGICAL LIGANDS
prokineticin-2β, prokineticin-1, prokineticin-2
STRUCTURE MODELS
STRUCTURES
No structures available